Biocatalytic Carboxylate Reduction – Recent Advances and New Enzymes

Carboxylate reductases (CARs) are valuable catalysts for the selective one-step reduction of carboxylic acids to their corresponding aldehydes. In recent years, numerous new CARs have been made available, studied and applied in context biocatalytic syntheses. The preparation aldehydes as end products flavor fragrance sector integration cascade reactions with key intermediates represent two major fields applications. This review gives a comprehensive overview current toolbox recombinant carboxylate substrates. Non-natural functions highlighted insight into structure-function relationship summarized.